Selank

Mechanism · Dosing · Effects

Selank is a synthetic heptapeptide analog of tuftsin with clinically documented anxiolytic, anti-asthenic, and nootropic effects. Unlike benzodiazepines, Selank shows no sedation, no dependence, and no withdrawal potential in human trials.
This summary presents a practical, once-daily subcutaneous (SC) protocol using a 10 mg vial for accurate dosing and clean titration.

Mechanism (how it works)

GABA & anxiolytic modulation

• Enhances GABAergic signaling → reduces anxiety without sedation.

Neuropeptide & immune regulation

• Modulates cytokine balance → stabilizes stress response and calmness.

Anti-asthenic effect

• Improves mental energy, motivation, and cognitive endurance.

Nootropic properties

• Supports attention, memory, learning, and mood stability.

Dosing & Reconstitution Guide (practical)

Route: Subcutaneous injection, once daily
Cycle length: Commonly 4 weeks on → 4 weeks off (repeat as desired)
Storage: Lyophilized frozen; reconstituted refrigerated (2–8 °C), protected from light

Reconstitution (standard approach)

• 10 mg vial + 3.0 mL bacteriostatic water → ~3.33 mg/mL
• 1 unit = ~33.3 mcg (U-100 insulin syringe)
• Ideal dilution for precise measurement of 300–500 mcg doses

Example titration (gradual protocol)

Weeks 1–2:
• 300 mcg (0.09 mL → 9 units)

Weeks 3–4:
• 500 mcg (0.15 mL → 15 units)

Optional cycling pattern:
• 5 days on, 2 days off
• Or 4 weeks on, 4 weeks off

Effects & Benefits

Anxiolytic effects (benzodiazepine-level, but non-sedative)

• Reduces anxiety
• No sedation, no motor impairment
• No dependence or withdrawal

Anti-asthenic benefits

• Increased mental energy and motivation
• Reduced stress-induced fatigue

Cognitive support

• Improved focus, clarity, and processing
• Enhanced memory encoding and stability

Side Effects & Safety Notes

Common

• Mild injection-site redness or itching
• Rare temporary headache

General notes

• Very wide therapeutic window
• No sedation or cognitive slowing
• Well tolerated in human trials across 14–28 days
• Rotate injection sites to reduce irritation
• Discontinue if unusual symptoms occur

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